GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| THCA | cis | rs2076028 | 1 | rs5750672 | chr22:39104168 | TOMM22 | chr22:39077954-39080763:+ | 0.25 | 5.48 | 6.77E-8 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs5750673 | chr22:39110124 | JOSD1 | chr22:39081549-39096459:- | -0.16 | -4.04 | 6.27E-5 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs5750673 | chr22:39110124 | TOMM22 | chr22:39077954-39080763:+ | -0.16 | -3.37 | 0.000827 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs5750677 | chr22:39147715 | LOC646851 | chr22:38974125-39052634:- | 0.18 | 4.58 | 5.99E-6 | Resting heart rate |
| THCA | cis | rs2076028 | 1 | rs5750677 | chr22:39147715 | SUN2 | chr22:39130735-39190161:- | 0.15 | 3.58 | 0.000377 | Resting heart rate |
| THCA | cis | rs5758659 | 1 | rs5751255 | chr22:42648408 | C22orf32 | chr22:42475699-42480287:+ | 0.2 | 5.29 | 1.85E-7 | Cognitive function |
| THCA | cis | rs5758659 | 1 | rs5751255 | chr22:42648408 | CCDC134 | chr22:42196678-42222303:+ | 0.21 | 3.97 | 8.28E-5 | Cognitive function |
| THCA | cis | rs5758659 | 1 | rs5751255 | chr22:42648408 | CYP2D6 | chr22:42522502-42526883:- | -0.41 | -10.76 | 2.6E-24 | Cognitive function |
| THCA | cis | rs5758659 | 1 | rs5751255 | chr22:42648408 | NAGA | chr22:42454339-42466846:- | 0.35 | 7.6 | 1.55E-13 | Cognitive function |
| THCA | cis | rs5758659 | 1 | rs5751255 | chr22:42648408 | WBP2NL | chr22:42120334-42454460:+ | 0.23 | 4.31 | 2.02E-5 | Cognitive function |
| THCA | cis | rs4038131 | 1 | rs57512806 | chr2:17776078 | GEN1 | chr2:17935162-17966632:+ | 0.51 | 6.8 | 3.05E-11 | Psychosis and Alzheimer's disease |
| THCA | cis | rs10794720 | 1 | rs57514701 | chr10:1146169 | IDI2 | chr10:1064847-1071799:- | 0.34 | 3.55 | 0.000417 | Chronic kidney disease;Glomerular filtration rate in non diabetics (creatinine) |
| THCA | cis | rs4820539 | 1 | rs5751589 | chr22:23475762 | GNAZ | chr22:23412669-23467221:+ | 0.29 | 6.19 | 1.26E-9 | Bone mineral density |
| THCA | cis | rs5751901 | 1 | rs5751901 | chr22:24992266 | GGT1 | chr22:24979718-25024972:+ | -0.37 | -7.32 | 1.06E-12 | Protein quantitative trait loci |
| THCA | cis | rs5751901 | 1 | rs5751901 | chr22:24992266 | LOC644165 | chr22:25028882-25049326:+ | 0.21 | 6.01 | 3.62E-9 | Protein quantitative trait loci |